Melatonin versus pregabalin as oral premedication in adult patients undergoing lower-extremity amputation under spinal anesthesia

Document Type : Original Article

Authors

1 Department of anesthesia , ICU &pain management ,Faculty of Medicine for girl Al-Azhar University ,Cairo, Egypt

2 department of anesthesia, intensive care and pain managment, Faculty of Medicine for Girls, Al-Azhar University.

3 Department of General Surgery, Faculty of Medicine for Girls, Al-Azhar University, Egypt

4 Department of anesthesiology ,intensive care & pain management,Faculty of Medicine for girls , Al-Azhar University

10.21608/aimj.2025.395278.2585

Abstract

Objectives: To assess how well pregabalin and melatonin work as premedication to reduce perioperative anxiety and post-surgical discomfort in individuals having lower limb amputations while given spinal anesthesia.
Methods: Participants were split up into two sets of 25 patients, M and P, who were undergoing surgical lower limb amputation at Al-Zahraa University Hospital, either above or below the knee, under spinal anesthesia. About two hours before spinal anesthesia, one melatonin pill 6 mg (Group M) or 150 mg of pregabalin capsules (Group P) was given to them.
Results: Compared to the pregabalin group, the melatonin group had more perioperative anxiousness. Pregabalin enhanced discomfort management and lessened the need for analgesics. The duration of motor block of spinal anesthesia was better for the pregabalin group. Higher levels of sedation were produced by melatonin.
Conclusion: Pregabalin performed better in terms of pain score, but melatonin was more effective at reducing anxiety and promoting sedation.

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