The value of Copeptin and Lung Ultrasound in Assessment of Volume Status in Chronic Regular Hemodialysis Patients

Rashed, Al Sayed Mohamed; Ayoub, Hazem Sayed Ahmed; Basiony, Fareed Shawqi; Abd El Salam, Abd El Salam Fathy; Elnewishy, Ibrahim Abd Elwhab

doi:https://doi.org/10.21608/aimj.2025.446651

The value of Copeptin and Lung Ultrasound in Assessment of Volume Status in Chronic Regular Hemodialysis Patients

Document Type : Original Article

Authors

¹ Department of Internal Medicine and Nephrology, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt.

² Department of Chest diseases, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt.

³ Department of Clinical Pathology, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt

https://doi.org/10.21608/aimj.2025.446651

Abstract

Background: Research indicates that copeptin levels are raised in cases with end-stage kidney disease (ESKD) and may serve as an alternate biomarker to vasopressin for predicting cardiovascular illnesses and death in end-stage kidney disease cases.
Aim: To assess the role of lung ultrasound and Copeptin in the assessment of volume status before and after a dialysis session in hemodialysis cases.
Patients and methods: The cross-sectional investigation comprised ninety cases of patients who had been diagnosed with chronic renal failure on regular dialysis and fulfilled the selection criteria from the Nephrology Unit, Al Hussein University Hospital. This was a prospective observational investigation performed at the Department of Internal Medicine, Faculty of Medicine, Al-Azhar University.
Results: A significant reduction has been observed in copeptin level post-hemodialysis than pre-hemodialysis (p<0.001). There was a significant positive association among copeptin, SBP, DBP, body weight, B-line score, and IVC diameter (p <0.001). There was a significant negative association between copeptin and IVC Collapsibility (p <0.001).
Conclusion: In summary, Copeptin and lung ultrasonography can evaluate fluid volume status. This provides an effective approach for assessing fluid status in cases with volume overload. Future directions could involve the expansion and application of lung ultrasonography and Copeptin for the quantitative assessment of volume status in additional volume-sensitive populations, like cases with heart failure.

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