Document Type : Original Article
Authors
1
Emergency and Critical Care Medicine, Faculty of Medicine, Al-Azhar University, Damietta, Egypt
2
Anasthesia and Intensive Care
3
Anesthesia, Intensive Care and Pain Management , Faculty of Medicine, Al-Azhar University, Damietta, Egypt
4
Clinical Pathology Department, Faculty of Medicine, Al-Azhar University, Damietta, Egypt
10.21608/aimj.2025.405587.2671
Abstract
Background: Unfortunately, over 5.3 million people die every year from sepsis, and septic shock is a pathological condition that affects a large percentage of intensive care unit patients. The complete blood count (CBC) includes white blood cells and red blood cell distribution width (RDW). Procalcitonin and interleukin 6 were among the biomarkers found in the circulation.
Aim: To assess and compare the diagnostic and prognostic capability of procalcitonin versus IL-6 versus complete blood count.
Patients and methods: Our single-center prospective cohort study was carried out on 100 patients with sepsis; 61% were males, and 39% were females, with age ranging from 25 to 85 years, with mean±SD of 56.6±16.3 years.
Results: What this study found Patients who did not make it had significantly higher levels of interleukin-6 on days 0, 3, 6, 9, and 12 compared to those who did, suggesting a statistically significant association between vital signs and sepsis severity, procalcitonin at different time intervals and sepsis severity, white blood cells at different time intervals and mortality, and finally, interleukin-6 at different time intervals and mortality.
Conclusion: In contrast to other diagnostic tools, procalcitonin is useful for distinguishing between deaths caused by sepsis and those caused by other causes. This makes it an ideal sepsis marker. IL-6 has the ability to serve as a biomarker for the diagnosis of sepsis and is a reliable predictor of this condition.
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