The Association Between Pri-Mir-34b/Crs4938723 Polymorphism and Risk of Hepatocellular Carcinoma in Egyptian Patients

Abdelwahed, Alyaa Sabry; Allam, Naglaa Allam Ahmed; Gomaa, Asmaa Ibrahim Elsayed; Aboelkheir, Sameera Ezzat; Ghanem, Heba Samy Mohamed; Ibrahim, Nehal Hamdi

doi:https://doi.org/10.21608/aimj.2025.446630

The Association Between Pri-Mir-34b/Crs4938723 Polymorphism and Risk of Hepatocellular Carcinoma in Egyptian Patients

Document Type : Original Article

Authors

¹ Hepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Menoufia, Egypt.

² Hepatology Department, National Liver Institute, Menoufia University, Menoufia, Egypt.

³ Public Health Epidemiology and Preventive Medicine Department, National Liver Institute, Menoufia University, Menoufia, Egypt.

⁴ Clinical Pathology Department, National Liver Institute, Menoufia University, Menoufia, Egypt.

⁵ Hepatology and Gastroenterology Department, Sheheen El Qanater Hospital, Al-Qalyubia, Egypt.

https://doi.org/10.21608/aimj.2025.446630

Abstract

Background: Hepatocellular carcinoma (HCC) is responsible for the fourth-highest mortality rate for both males and females.
Aim of the work: To gain a better understanding of the relationship between the pri-miR-34b/crs4938723 genetic variation and the risk of stomach cancer in Egyptian people.
Patients and methods: This case control study, conducted on 100 patients attended the inpatient unit and the outpatient clinics of the Hepatology department, National Liver Institute and 100 healthy volunteers age, and gender matched enrolled as a control group.
Results: The HCC group had a higher frequency of the variant C allele of the pri-miR-34b/c rs4938723 SNP than the healthy control group (p=0.015). Similar results were found for the genotypic distribution (p=0.041) and recessive genetic model (p=0.032). Different genotypes had significantly different focal lesion sizes and multiplicity. A small percentage of CC, TC, and TT genotype patients had focal lesion symptoms. Despite this, 66.7% of CC genotype patients, 43.1% of TC genotype patients, and 17.9% of TT genotype patients had small focal lesions (P 0.002). Patients with one focal lesion were 33.3% for the CC genotype, 49.0% for the TC genotype, and 78.6% for the TT genotype, while those with two or more lesions were 66.7%, 51.0%, and 21.4%, respectively (P 0.004).
Conclusions: pr-miR-34b/crs4938723 hydrogel. The TT genotype has the potential to be a non-invasive diagnostic tool for predicting the development of HCC in the Egyptian population.

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