Document Type : Original Article
Authors
1
Assistant Professor of Cardiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt
2
MBBCh, Faculty of Medicine, Al-Azhar University, Damietta, Egypt
https://doi.org/10.21608/aimj.2025.446586
Abstract
Background: There are 18 million fatalities a year due to cardiovascular disease, making it the top cause of death globally. Coronary artery disease (CAD) risk factors include dyslipidemia, which is clearly one of the most important ones.
Aim and objectives: To assess plaque burden and cardiovascular risk in relation to the level of lipoprotein (a) (Lp (a)).
Subjects and methods: The purpose of this cross-sectional study was to evaluate the plaque burden in 56 patients who underwent coronary angiography (CA) and intravascular ultrasonography at the National Heart Institute's Cardiology Department between October 2022 and June 2023. They were divided into two categories based on lipoprotein (a) levels: Patients in Group A (n=22) had lipoprotein levels of 60 mg/dl or higher; patients in Group B (n=34) had lipoprotein levels of 60 mg/dl or lower.
Results: Group A had significantly higher mean values of serum TG, LDL, cholesterol, and uric acid compared to group B (p=0.04, 0.07, 0.018, and 0.032, respectively). With R-values of 0.439, 0.311, 0.418, 0.347, and 0.325, respectively, the levels of intravascular ultrasound (IVUS), serum cholesterol, serum TG, LDL, and serum uric acid were positively correlated with the percentage of atheroma volume (PAV) as measured by intravascular ultrasound (IVUS).
Conclusion: Elevated Lp (a) correlates with greater coronary atheroma volume. High blood Lp(a) levels are linked to negative consequences.
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