The effect of intravenous tranexamic acid in reducing blood loss in vaginal delivery

Document Type : Original Article

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Department of Obstetrics and Gynecology, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt.

https://doi.org/10.21608/aimj.2025.446574

Abstract

Background: Postpartum haemorrhage (PPH) is a significant global complication following caesarean and vaginal deliveries that significantly raises the risk of maternal death and close calls.
Aim: To ascertain how prophylactic tranexamic acid (TA) affects observed and computed blood loss during the vaginal birth.
Patients and methods: 120 women with singleton pregnancies participated in this randomised controlled experiment, which ran from December 2021 to June 2022 at the Obstetrics and Gynaecology department at AL-HUSSIEN University Hospital and Isis Specialised Hospital for Obstetrics and Gynaecology in Luxor. After the foetus was delivered, women were randomly randomised to receive 10 IU of oxytocin and one gramme of intravenous TA or a placebo. Only the personnel were aware of which patients were on which regimen.
Results:  There was no significant difference in hemoglobin pre-operatively between the groups, but a significant decrease in hemoglobin post-operatively. Intraoperative events were not significantly different, but total blood loss was significantly different (P <0.001).
Conclusion:  Since no woman is immune to postpartum haemorrhage, intravenous TXA, when given to avoid primary PPH, reduces the loss of blood after vaginal birth safely and efficiently with no increased maternal risks. As such, it ought to be made accessible to women who are chosen for a vaginal delivery.
 
 

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