Photodynamic Therapy Versus Its Combination with Fractional Carbon Dioxide Laser in The Treatment of Onychomycosis: A Randomized Controlled Trial

Document Type : Original Article

Authors

1 Professor of Dermatology and Venereology; Al-Azhar Faculty of Medicine, Cairo

2 Assistant lecturer of Dermatology and Venereology; Al-Azhar Faculty of Medicine, Cairo

https://doi.org/10.21608/aimj.2025.446572

Abstract

This study explores an alternative approach to managing onychomycosis, a persistent fungal nail infection often resistant to conventional treatments due to prolonged therapy duration, potential liver toxicity, and limited drug penetration into the nail. The research assesses the efficacy of combining photodynamic therapy (PDT) with fractional CO2 laser treatment. A total of 20 patients were categorized into two groups: one receiving PDT alone, and the other undergoing a combination of PDT and Fractional CO2 treatments. The combined approach yielded the most favorable outcomes in achieving complete nail clearance. These findings suggest that integrating PDT with fractional CO2 laser therapy may enhance treatment effectiveness compared to PDT alone, though additional studies are necessary to determine long-term outcomes.
 

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