Carbetocin Versus Oxytocin for the Prevention of Atonic Postpartum Hemorrhage after Elective Caesarean Section in High Risk Women

Farag, Sameh Said; Elshahat, Elmetwally Farouk; Rabie, Ahmed Bashir

doi:https://doi.org/10.21608/aimj.2025.446569

Carbetocin Versus Oxytocin for the Prevention of Atonic Postpartum Hemorrhage after Elective Caesarean Section in High Risk Women

Document Type : Original Article

Authors

¹ Professor of Obstetrics and Gynecology, Faculty of Medicine for boys, Al-Azhar University, Cairo, Egypt

² Lecturer of Obstetrics and Gynecology, Faculty of Medicine for boys, Al-Azhar University, Cairo, Egypt

³ MBBCh, and Diploma in Obstetrics and Gynecology, Obstetrician and Gynecologist, Aga Central Hospital, Egypt

https://doi.org/10.21608/aimj.2025.446569

Abstract

Background: One leading cause of maternal illness and death is postpartum hemorrhage. Ten percent or more of all births include it, and it's the leading cause of maternal mortality (at 25%).
Aim and objectives: When it came to preventing atonic postpartum hemorrhage (PPH), we compared carbetocin with oxytocin in high-risk women who had elective cesarean sections to find out which one was safer and more successful.
Subjects and methods: There were two equal groups of 200 women who underwent elective cesarean sections under regional anesthesia and were at high risk for primary atonic postpartum hemorrhage (defined as a gestational age of more than 37 weeks): In the first group, 100 women were given 100 micrograms of carbetocin intravenously. 100 women made up Group II; each of them got 10 IU of oxytocin intravenously. We examined the effects of the two medications on uterine atony, blood loss, and pre- and post-operative vital sign changes.
Results: The two drugs' expected blood loss was substantially different (p=0.002). In addition, the two drugs differed significantly (p=0.048) in their effects on postpartum blood loss. The two drugs were not statistically comparable when it came to supplemental needs, such as the need for more uterotonic therapy or blood transfusions.
Conclusion: Preventing atonic postpartum hemorrhage and reducing intrapartum hemorrhage are both improved by carbetocin. When it came to the administration of extra oxytocic drugs and blood transfusions, though, carbetocin and oxytocin were identical.

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