Effect of Nutritional Status on Quality Of Life of Hepatocellular Carcinoma Patients: A Cross-Sectional Study

Document Type : Original Article

Authors

1 Department of Epidemiology and Preventive Medicine, National Liver Institute, Menoufia University, Egypt

2 Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Egypt

https://doi.org/10.21608/aimj.2025.446567

Abstract

Background: Patients with advanced cancer frequently suffer from malnutrition, which is related to a poor treatment response and a crucial reduction in quality of life (QOL). However, there is little evidence studying the relationship between QOL and malnutrition in HCC patients.
 Aim of study:  To evaluate the relation between the nutritional status and quality of life of Egyptian HCC patients at the outpatient clinic at National Liver Institute Hospital, Menoufia University.
Patients and methods: 200 HCC patients were involved in this analytical cross-sectional study from the outpatient clinics at the National Liver Institute. Body Mass Index (BMI), Mid Muscle Arm Circumference (MMAC), Mid Arm Circumference (MAC), Calf Circumference (CC), Hand Grip Strength (HGS), Adductor Pollicis Muscle (APM) thickness, Mini-nutritional Assessment (MNA), and Subjective Global Assessment (SGA) Questionnaire were used to assess nutritional status. The Core Quality of Life questionnaire (EORTC QLQ-C30), developed by the European Organization for Research and Treatment of Cancer, was used to measure QOL.
Results: High statistical significant association was found between the domains of EORTC QLQ-C30 and different nutritional assessment tools. Nutritional status is a predictive factor for QOL.
Conclusions: There is a highly statistically significant correlation between nutrition status assessment methods and QOL of HCC patients. Nutritional status determines QOL in HCC patients more than child classification and the Barcelona Clinic Liver Cancer (BCLC) stage.
 
 

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