The Role of Prophylactic Use of Low Dose Aspirin and Calheparin in Patients with Unexplained Recurrent Abortion

Document Type : Original Article

Authors

Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

10.21608/aimj.2025.446541

Abstract

Background: Two or more miscarriages occurring within a 20-week window constitute recurrent pregnancy loss (RPL). A small percentage of pregnancies (1% to 5%) involve RPL. The causes of miscarriage are unknown in 40% of cases, which is categorized as an unjustified RPL (URPL), even though many factors are involved in approximately 60% of RPLs. These factors include environmental factors, stress, chromosomal abnormalities, coagulation protein defects, anatomic endocrine disorders, and the autonomic immune system.
Aim and objectives: To assess the efficacy of low-dose aspirin and calheparin used as a preventative measure in women experiencing unexplained recurrent abortions.
Patients and methods: The study was a prospective interventional study that included 60 patients who were selected from attendee of out-patient Obstetrics and Gynecology clinics of Al-Azhar at Al-Hussien and Sayed Gala University Hospitals from January 2024 till December 2024. Samples were collected using a random systematic method.
Results: Regarding the outcome, 46 (76.67%) patients passed the first trimester, whereas abortion occurred in 14 (23.33%) patients.
Conclusion: For women experiencing unexplained repeated abortions, a safe and effective treatment option is a combination of low-dose aspirin and calheparin, which can reduce the abortion rate and help them safely pass the first trimester. There is a small risk of temporary thrombocytopenia, gastrointestinal problems, bruising at the injection site, epistaxis, and bleeding gums when women with unexplained recurrent abortions take a low dose of aspirin and calheparin.

Keywords

Files

Share

How to cite

Statistics