Comparative study between the Efficacy of Topical Sildenafil 2% and Topical Minoxidil 5% in the Treatment of Male Androgenic Alopecia

Ibraheem, Mohammed Kotb; Amer, Mohammed Abd El Mawgoud; Mansour, Hamdy Abdou; Abd El Ati, Yassir Hagag Mohammed

doi:10.21608/aimj.2025.446532

Comparative study between the Efficacy of Topical Sildenafil 2% and Topical Minoxidil 5% in the Treatment of Male Androgenic Alopecia

Document Type : Original Article

Authors

¹ Dermatology, Venerology and Andrology, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt

² Medical Pharmacology, Faculty of Medicine, Al-Azhar, University, Cairo, Egypt

10.21608/aimj.2025.446532

Abstract

Background: In genetically predisposed people, androgen-induced hair thinning is known as androgenic alopecia(AGA). It has a hereditary tendency and is a multifactorial and polygenetic disorder.
Aims and objectives: To contrast topical minoxidil 5% and topical sildenafil 2% in terms of their effectiveness in treating male androgenic hair loss.
Subjects and methods: Fifty patients with androgenic alopecia were included in the present investigation according to their clinical and dermoscopic diagnoses. Two groups of twenty-five patients each were formed from the patients. For six months, Group A was administered topical sildenafil 2% twice a day. Similarly, Group B was administered topical minoxidil 5% twice a day.
Result: Age and vertex hair thickness showed a strong positive association, according to the topical Minoxidil 5% group. However, there was no discernible relationship between the others. VH responses at the frontal region and patient satisfaction showed a significant positive association, based on the topical Sildenafil 2% group. Age and the length of AGA were significantly and negatively correlated with the VH activity in the vertex region. Age and the length of AGA were significantly and negatively correlated with frontal area hair thickness. Age and the duration of AGA were significantly positively correlated with hair density at the frontal and vertex regions.
Conclusion: The research found that while topical minoxidil 5% is currently the most common treatment for treating AGA due to its great tolerability and patient satisfaction, topical sildenafil 2% therapy is a promising alternative.

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