Immunohistochemical Expression of Ki67 in Relation to Colposcopic Findings in Pateints with Cervical Intra Epithelial Neoplasia

Hamdy, Inas Mahmoud; Ali, Reham Saeed Mohamed; Salama, Doaa Al Said Abd Alaziz; Nabih, Asmaa El Sayed

doi:10.21608/aimj.2025.446531

Immunohistochemical Expression of Ki67 in Relation to Colposcopic Findings in Pateints with Cervical Intra Epithelial Neoplasia

Document Type : Original Article

Authors

¹ Obstetrics and Gynecology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

² Histopathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

10.21608/aimj.2025.446531

Abstract

Background: Cervical cancer develops from cervical intraepithelial neoplasia(CIN) grades I, II, and III, which are a defined set of preneoplastic lesions characterized by progressive cellular abnormalities. Over the past 20 years, numerous epidemiological studies have found that HPV types 16 and 18, which are considered high risk, are strongly associated with cervical cancer in as many as 95% of cases.
Aim of the work: To study Immunohistochemical Expression of(Ki-67) in relation to colposcopic findings in patients with cervical intraepithelial neoplasia (CIN1, CIN2, and CIN3).
Patient and method: This Prospective Cross-Section Interventional Study was conducted in colposcopy unit at Al-Zahraa University Hospital, data was collected from April 2021 till June 2023. Including 306-patients those attended to colposcopy unit. All of them subjected to Pap smear, colposcopic examination, cervical biopsy and Ki67 immunohistochimechal staining.
Results: Researchers found a statistically significant correlation between CIN patients' levels of sexual activity and their Ki-67 expression scores. As a means of predicting CIN, this study found that colposcopy had a PPV of 52.2% and a sensitivity of 92.2% and a specificity of 30.1%. This study showed that sensitivity and specificity of Ki67 as immmunohistochemical marker in prediction of CIN were 84.4%, 100% respectively and its PPV is 100%.
Conclusion: Sensitivity and specificity of colposcopy as method of prediction of CIN were 92.2%,30.1% respectively and its PPV is 52.2% comparing to immunohistochemestry sensitivity and specificity of Ki67 as immmunohistochemical marker in prediction of CIN were 84.4%, 100% respectively and its PPV is 100% which means that Ki67 improve accuracy of prediction of CIN.

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