Tadalafil Monotherapy versus Tadalafil Combined Pumpkin seed oil in Treatment of Men with Chronic Pelvic Pain Syndrome

Document Type : Original Article

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Urology, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt

10.21608/aimj.2025.446526

Abstract

Background: Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a clinical condition defined by pelvic and perineal discomfort along with symptoms affecting the lower urinary tract, also accompanied by sexual dysfunction.
 Aim and objectives: To investigate the efficacy of Tadalafil monotherapy versus Tadalafil combined with Pumpkin seed oil (PSO) in the treatment of men with CP/CPPS who complain of erectile dysfunction(ED).
Patients and methods: This randomized prospective study was performed at the Urology Department of Al Azhar University Hospitals in Cairo, Egypt, from November 2023 to October 2024. The study included 50 patients diagnosed with (CP/CPPS), all patients were assigned randomly into Group(A) which consisted of 25 patients who were given 5 mg of Tadalafil at bedtime for (12)weeks and Group(B), which also consisted of 25 patients who received 5 mg of Tadalafil along with a 1010 mg (PSO) capsule at bedtime for (12)weeks and patients followed monthely for (3)months.
Results: In Group(A),12 patients(48%) showed clinically significant improvement, while 11 patients(44%) in Group(B) experienced similar improvements.
Conclusion: Both Tadalafil and the combination of Tadalafil with (PSO) significantly improved symptoms in CP/CPPS patients with mild to moderate ED. However, the addition of (PSO) did not show greater effectiveness compared to Tadalafil alone, except for the pain domain.

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