Estimation of Transferrin Receptor (CD71) Representation on T CELLS tending from Patients with Rheumatoid Arthritis

Document Type : Original Article

Authors

1 Clinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

2 Rheumatology and Rehabilitation, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt

10.21608/aimj.2025.446517

Abstract

Background: Damage to joints and non-articular organs such as the heart, kidneys, lungs, digestive system, eyes, skin, and nervous system can occur in rheumatoid arthritis(RA), a systemic autoimmune disease characterized by a persistent inflammatory process.
Aim and objectives: To estimate transferrin receptor(CD71) representation on T cells in patients with RA.
Subjects and methods: In this study, twenty patients were examined between March 2024 and October 2024 at Al-Hussien Hospital, Al-Azhar University, after being referred to the clinical pathology department from the rheumatology department.
Results: CD71 and CD3 were increased in all RA patients in relation to the control group. CD71 has a role in the activity of RA. CD71 was low in controlled patients and increased in increased activity of RA. CD3 has been shown to be related to the reactivity of the disease, which ensures it is a T-lymphocyte-related autoimmune disease.
Conclusion: CD71 has a role in activity and is low in controlled patients and increases in patients with increased activity of RA.CD3 has been shown to be related to the reactivity of the disease, which ensures it is a T-lymphocyte-related autoimmune disease. So, assessment of CD71 and CD3 is very helpful in the assessment of activity in rheumatoid patients.

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