Study of the Role of Erythrocyte Glutathione Transferase as A potential Marker of Haemodialysis Adequacy

Mowafy, Nagwa Mohammed; Khedr, Muhammad Abd Alhameed Basyony; Ebrahim, Farag Khalil Farag; Aleysawy, Mohamed Abed Al Kareem Soliman

doi:https://doi.org/10.21608/aimj.2025.446496

Study of the Role of Erythrocyte Glutathione Transferase as A potential Marker of Haemodialysis Adequacy

Document Type : Original Article

Authors

¹ Professor of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

² Assistant Professor of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

³ Professor of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

⁴ MBBCh, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

https://doi.org/10.21608/aimj.2025.446496

Abstract

Abstract

Background: The high prevalence of complications and fatalities caused by end-stage renal disease (ESRD) makes it a major issue in global public health. Over the past three decades, the prevalence of chronic kidney disease (CKD) has increased dramatically on a global scale. ‏
Aim and objectives: Our goal is to find out whether erythrocyte glutathione transferase (E-GST) is just another urea measurement that goes along with Kt/V hemodialysis (HD) or if it's a new way to tell if dialysis is working well.
Patients and methods: In this cross-sectional study, which lasted from August 2023 to August 2024 and was structured according to hemodialysis mode, forty patients with end-stage renal disease (ESRD) who were regularly treated at the hemodialysis units of Al-Hussein and Said Galal Al-Azhar university hospitals were included. Patients were divided into two equal groups according to gender and age.
Results: When it comes to measuring hemodialysis adequacy, E-GST is just as effective as URR and Kt/V Urea. It serves as an additional indicator that reflects URR and Kt/V values, and there is no statistically significant distinction between traditional HD and post-dilutional online hemofiltration (OL-HDF) (P-value>0.05).
Conclusion: Hemodialysis adequacy and the elimination of toxins in multiple sessions by different hemodialysis modalities can be expressed by the amount of E-GST, a hemodialysis patient marker that is both sensitive and specific.

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