Noninvasive Estimation of Left Ventricular Diastolic Function in Patients with Hypertension and Normal Ejection Fraction Using 2-Dimensional Speckle Tracking Echocardiography

Document Type : Original Article

Authors

Cardiology department, Al-Azhar university Faculty of medicine, Cairo, Egypt.

https://doi.org/10.21608/aimj.2025.446471

Abstract

Background: Hypertension leads to increased left ventricular (LV) wall stress, afterload, and remodeling, resulting in diastolic dysfunction and hypertensive heart disease. Assessing LV end-diastolic pressure (LVEDP) is crucial for early detection of diastolic impairment.
Aim: To assess diastolic function, with a particular focus on (LVEDP), in hypertensive patients utilizing speckle tracking echocardiography (STE), a non-invasive technique, to compare the non-invasive findings obtained from (STE) with the invasive measurements acquired through cardiac catheterization.
Methods: This study compares LVEDP in 25 hypertensive vs. 25 normotensive patients using invasive catheterization and echocardiography-derived KT index, which states that Estimated LVEDP= 10.8–12.4 [KT index] where KT index equals [log10 (active LAEF/minimum LAV)].
Results: Hypertensive patients showed significantly elevated estimated LVEDP (p < 0.0011), measured LVEDP (p < 0.0011) than the upper limit of normal LVEDP. Passive and active left atrial ejection fractions (LAEF%) were significantly reduced (p < 0.0011), indicating impaired atrial function. Wilcoxon analysis confirmed a strong correlation between estimated and measured LVEDP (p < 0.001).
Conclusion: Speckle tracking echocardiography provides a reliable, non-invasive method for detecting diastolic dysfunction, demonstrating a strong association between hypertension and elevated LVEDP.
 

Keywords

Files

Share

How to cite

Statistics