Combined Sildenafil and Dapoxetine versus Sildenafil Alone in the Treatment of Dapoxetine Non-Responding Mono-symptomatic Premature Ejaculation: A Randomized Comparative Study

Document Type : Original Article

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Department of Urology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

https://doi.org/10.21608/aimj.2025.446470

Abstract

 
Background: Septic shock, a critical condition marked by circulatory failure and organ dysfunction from an abnormal response to infection, requires immediate hemodynamic resuscitation to restore tissue perfusion and improve outcomes. This study assessed changes in hemodynamic parameters in septic shock patients before and after fluid resuscitation.
Aim: To evaluate the hemodynamic changes before and after resuscitation by either colloids or crystalloids  .
Patient and Methods: 60 patients with septic shock in the emergency and critical care departments of Al-Azhar University Hospitals were divided into two groups, A and B, with 30 patients in each group. Hemodynamic parameters such as blood pressure were measured at baseline and three hours after administering 30 mL/kg fluid resuscitation according to standard guidelines. The effects of saline versus albumin were also compared.
Conclusion: Marked hemodynamic improvements occurred following protocolized resuscitation, with crystalloids achieving the best corrections.
 

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