Controlling Antibiotic resistance through antibiotic stewardship at Al-Hussin University Hospital

Document Type : Original Article

Authors

Department of Clinical Pathology, Faculty of Medicine for boys, Al-Azhar University, Cairo, Egypt.

https://doi.org/10.21608/aimj.2025.446467

Abstract

 
Background: Among the most deadly types of hospital-acquired infections, those involving central venous catheters account for over half of all cases. These infections lead to longer hospital stays, higher medical bills, and even death for patients. The majority of current methods for preventing catheter-associated infections involve the use of antibiotics; however, due to the worldwide increase in antibiotic resistance, these medications are often rendered useless.
The aim of the work: Is to help clinicians select the best empiric antimicrobial treatment in emergency cases or after major surgery to achieve more rapid administration of effective antimicrobial therapy and decrease multidrug resistance.  
Patients and Methods: This descriptive observational study involved 200 patients admitted to different intensive care units (ICUs) at Al-Hussin University Hospital. These patients were exposed to bacterial infections, and samples were collected. All samples were subjected to bacterial culture and antibiotic sensitivity testing.
Results: The study was conducted on 200 patients, including Gram-negative (76%) and Gram-positive (24%) isolates. The most common isolated bacteria were Klebsiella spp. (45.5%) followed by E. coli (23%), then methicillin-sensitive Staphylococcus aureus (MSSA) (13.5%), methicillin-resistant Staphylococcus aureus (MRSA)  (10.5%),  and Pseudomonas spp. (7.5%). This study showed 98.08% Colistin (CL) susceptibility and 95.28% Tigecycline (TGC) susceptibility for Klebsiella spp., in addition to 96.82% Colistin susceptibility and 97.34% Tigecycline susceptibility for E. coli.
Conclusion: Colistin and Tigecycline should be considered as the most effective drugs. The antibiotic stewardship committee should meet monthly for follow-up and every three months to present updates to hospital management and updates on antibiograms if necessary.
 

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