Effect of Acute Disturbance of kidney Function on Weaning from Mechanical Ventilation in Intensive Care Unit Patients

Ibrahim, Atef Abou Elfotouh; Abou Elhassan, Ahmed Mohamed Ahmed; Abd El Aziz, Ahmed Fathy; Youssef, Ayman Ahmed Youssef

doi:https://doi.org/10.21608/aimj.2025.446464

Effect of Acute Disturbance of kidney Function on Weaning from Mechanical Ventilation in Intensive Care Unit Patients

Document Type : Original Article

Authors

¹ Professor of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt;

² Professor of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

³ MSc, Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

https://doi.org/10.21608/aimj.2025.446464

Abstract

Abstract

Background: One of the leading causes of organ failure, especially in critically ill patients, acute kidney injury (AKI) poses a significant risk of morbidity and mortality with even a single episode, regardless of stage.
Aim and objectives: The goal is to determine how patients in the intensive care unit (ICU) fare after weaning off mechanical ventilation (MV) due to acute renal function disruption.
Patients and methods: Following approval from the Research Ethical Committee, this observational study was carried out from March 2022 to October 2024 on 100 patients undergoing invasive MV in the medical intensive care unit of Al-Azhar University Hospitals.
Results: Longitudinal differences in MV and weaning duration were statistically significant between the two groups. The acute kidney dysfunction group's patients needed MV for longer and were slower to wean from it. Acute renal failure patients were more likely to have weaning failure, whereas those with sufficient renal function had a higher rate of weaning success.
Conclusion: The results of patients receiving MV are greatly affected by acute kidney injury (AKI). In severely sick patients, AKI is linked to a higher mortality rate, a longer MV duration, and a longer weaning period. Results like this highlight how much of a toll AKI takes on both patient recuperation and intensive care unit resources.

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