Comparative Study of Using (Acvtivin-A levels) as A New Tool in the Diagnosis of Ectopic Pregnancy

El-Ebeisey, Hanaa Abd El-Hamid; Hamdy, Noha Mahmoud; El-Hawary, Mona Ameen; Mohamed, Fatma Badr Sayed

doi:10.21608/aimj.2025.446449

Comparative Study of Using (Acvtivin-A levels) as A New Tool in the Diagnosis of Ectopic Pregnancy

Document Type : Original Article

Authors

¹ Obstetrics and Gynecology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

² Clinical Pathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

10.21608/aimj.2025.446449

Abstract

Background: Ectopic pregnancy (EP) is a significant global health concern. It happens when a blastocyst abnormally implants outside the endometrium of the uterus. It is implanted in the fallopian tube in over ninety-five percent of cases.
Aim: To detect Activin-A early in maternal blood and determine if it can help in the diagnosis of early ectopic pregnancy.
Patients and Methods: This prospective case control research has been performed on 89 cases, subjects were classified into 2 groups: Group 1: 45 cases diagnosed with tubal ectopic pregnancy confirmed by serum β-HCG and transvaginal ultrasound and Group 2: 44 cases with normal pregnancy at the obstetrics and gynecology department, Al-Zahraa University Hospital.
Results: The association of serum Activin A (nanogram per milliliter) with clinical examination and TVS finding (pain, bleeding, presence of Mass, side of Mass and presence of free fluid) of cases with ectopic pregnancy and revealed insignificant positive association among Activin A concentrations and abdominal pain (r-value=0.013, p-value=0.893), bleeding (r=0.073, P=0.633). In contrast, a negative and insignificant association between Activin A and the presence of Mass was observed (r-value =-0.128, P-value =0.403). Conversely, a negative but not statistically significant association was found between Activin A and the presence of free fluid (r=-0.185, P=0.224).
Conclusion: This study concluded that ectopic pregnancy is a frequent and severe condition with a high rate of morbidity and the risk of maternal death. There was no significant association between ectopic pregnancy and Activin-A level. Activin-A was a poor marker for ectopic pregnancy in early diagnosed cases.

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