Monocyte/Lymphocyte And Monocyte/ Neutrophil Ratios As Predictors Of Cardiovascular Events In Hemodialysis Patients

Mohamed, Ragaa Ramadan; Maghraby, Hend Maghraby; Abd El-Fattah, Doaa Aly; Yousef, Shereen Yousef Salah; Sayed, Rania Fahmy Seif

doi:10.21608/aimj.2025.446447

Monocyte/Lymphocyte And Monocyte/ Neutrophil Ratios As Predictors Of Cardiovascular Events In Hemodialysis Patients

Document Type : Original Article

Authors

¹ Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

² Clinical Pathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

³ General internal medicine and kidney fellow, Head of the Kidney Department, Ahmed Maher Teaching Hospital, Cairo, Egypt

10.21608/aimj.2025.446447

Abstract

Background: Cases with chronic kidney illness stage 5 who are undergoing dialysis have noticed a rise in their probability of surviving in the past few years.
Aim: To assess the monocyte to neutrophil ratio and monocyte to lymphocyte ratio as indicators of cardiovascular events in end-stage renal illness cases on regular hemodialysis.
Patients and methods: This cross-sectional research involved 150 stable cases with end-stage renal disease undergoing regular HD for more than six months. Patients were recruited from the Hemodialysis Unit and the Nephrology Unit of EL Zahraa University Hospital, Homayat Imbaba and Ahmed Maher teaching Hospitals over a period of 6 months after oral and written consents and after the agreement of the ethical committee of the university.
Results: MLR was statistically significantly higher among group one cases (p-value= 0.006), and MNR was also statistically significantly higher among group one cases (p-value= 0.03). MNR was significantly positively correlated with age (p-value= 0.015, r-value=0.198), monocytes (p-value= 0.001, r=0.79) and LDL (p-value=0.03, r=0.18), while MNR showed significant negative correlation with both WBC (r= -0.29, p-value=0.001) and neutrophils (r= -0.51, p-value=0.001). MLR was a significant predictor for Cardiovascular Events in Hemodialysis Patients, p 0.001.
Conclusion: Monocyte to lymphocyte ratio (MLR), and monocyte to neutrophil ratio (MNR) are potential indicators of cardiovascular events in ESRD patients on regular hemodialysis. They show significant correlations with age, monocytes, LDL, and MNR, while being negatively correlated with WBCs and neutrophils.

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