Evaluation of Therapeutic Effect of Low Dose Enoxaparin in Treatment of Psoriasis: Pilot Study

Document Type : Original Article

Authors

Dermatology, Venereology and Andrology, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt

Abstract

Background: Psoriasis is an inflammatory skin condition that manifests as red, plaque-like lesions that are often covered with silvery-white scales. It is a chronic and recurrent immune-mediated skin disease.
Aim and objectives: To assess the safety and effectiveness of treating plaque psoriasis with low doses of enoxaparin.
Patients and methods: This study was conducted on 30 patients with plaque psoriasis(43.3%) males and(56.7%) females with a mean age of (37.7±13) years, ranging between(18-59) years, the patients had a mean disease duration (5.1±3.6) years, ranged between (1-16) years. Each patient was treated by 5mg enoxaparin(Clexane) as a subcutane­ous injection once a week for 12 weeks.
Results: There was statistically significant improvement in clinical response as 6 patients(20%) showed significant change, 12 patients(40%) showed moderate change, 8 patients (26.7%) showed no significant change, and finally, 4 patients(13.3%) were worsened.
Conclusion: The excellent side-effect profile of low-dose enoxaparin makes it a promising new therapeutic choice for psoriasis. Concerning efficacy, additional large-scale trials are needed to ascertain the optimal dose and length of treatment, the subgroup of psoriasis to be treated, and to compare enoxaparin to conventional psoriasis remedies.

Keywords

Al-Azhar International Medical Journal
Volume 2025, Issue 2
February 2025
Pages 195-201

Files

Share

How to cite

Statistics