Study of The Safety and Efficacy of Different Esomeprazole Containing Regimens for Eradication of Helicobacter Pylori Infection

Document Type : Original Article

Authors

1 Internal Medicine, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt

2 Clinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt

Abstract

Background: One of the most prevalent chronic bacterial illnesses affecting humans is Helicobacter pylori (H. pylori). Helicobacter pylori has colonized more than 50% of the global population. Infection with Helicobacter pylori can affect as many as 80% of the population in some nations, such as Egypt; however, this number varies widely around the globe.
Aim and objectives: To determine which esomeprazole-containing regimens are safest and most effective in eliminating H. pylori infection.
Patients and methods: This is a prospective observational study carried out on 120-patients. The material of the present study included H. Pylori patients who were recruited form Al-Hussein Hospital, internal medicine outpatient clinics from April 2023 and April2024.
Results: H. pylori eradication rate after esomeprazole-based regimen was 70.8%. Eradication rate did not significantly differ between different esomeprazole-based regimens. Also, patients reported adverse events had significantly lower eradication rate of H. pylori.
Conclusion: The overall eradication rate of H. pylori using esomeprazole-based regimens was 70.8%, indicating moderate efficacy across different treatment protocols. The eradication rates were similar across all five esomeprazole-based regimens, suggesting that the efficiency of the antibiotic combinations used was not significantly different.

Keywords

Al-Azhar International Medical Journal
Volume 2025, Issue 2
February 2025
Pages 177-182

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