Relation Between Adropin Levels and Hyperhomocysteinemia in Patients with Coronary Artery Disease

Authors

1 Cardiology Department, Faculty of Medicine for Girls, Al-Azhar University, Nasr City, Cairo, Egypt

2 Endocrinology Department, Faculty of Medicine for Girls, Al-Azhar University, Nasr City, Cairo, Egypt

3 Internal Medicine Department, Faculty of Medicine for Girls, Al-Azhar University, Nasr City, Cairo, Egypt

4 Clinical Pathology Department, Alzahraa University Hospital, Abbasiya neighbourhood, Cairo, Egypt

Abstract

Background and aim: Homocysteine and adropin effects on endothelial function are antagonistic. The current study aimed to evaluate the association between serum levels of adropin and homocysteine and the severity of coronary artery disease (CAD) . Patients and methods: This cross-sectional study included 86 patients submitted to coronary angiography with ≥ 50% stenosis in one or more coronary arteries. Serum Adropin and homocysteine levels were estimated. The anatomical synergy between percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score was utilized to assess the severity of CAD. Results: According to serum homocysteine levels, they were classified into patients with normal homocysteine levels (GI; n=54) and patients with hyperhomocysteinemia (GII; n=32). Comparison between the studied groups regarding clinical and laboratory findings revealed that GI patients had significantly shorter duration of diabetes (3.8 ± 5.3 versus 8.2 ± 7.5 years, p=0.009), higher serum triglycerides levels (204.7 ± 99.6 versus 142.9 ± 55.6 mg/dL, p=0.002), lower HbA1c levels (7.2 ± 1.6 versus 8.2 ± 2.0%; p = 0.013) and significantly higher adropin levels (7.4 ± 2.5 versus 1.6 ±1.0, p

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