Correlation between Serum Leptin with Severity of Knee Osteoarthritis

Authors

1 Department of Rheumatology and Rehabilitation, Faculty of Medicine, Al Azhar University

2 Department of Clinical Pathology, Faculty of Medicine, Al Azhar University

Abstract

Background: Knee osteoarthritis (OA), is a joint degeneration in the knee. due to progressive articular cartilage loss. Knee OA patients’ quality of life may be impacted by pain, physical restrictions, subpar treatment results, and more medication. Objective: correlation of serum leptin level with severity of knee osteoarthritis. Patients and Methods: This study involved 100 adult participants. (40-60 years old) presented to Egyptian railway medical center at outpatient clinics to correlate serum level of leptin with severity of knee osteoarthritis. Results: Our study also showed that cut off leptin level between OA patient and normal population is 13.6 mg/dl and it has 92.68 % sensitivity and 90% Specificity to OA. Although we can not rule out the psychological component in measuring pain in included patient but it’s important to consider that the study patients were not subjected to psychological assessment, additionally, researches in the future with a larger sample size are necessary to confirm our findings, although there are also, as far as we are aware, several studies were done to investigate the function of leptin in pathophysiology of osteoarthritis. Conclusion: Considering this study, knee OA patients had higher level of serum leptin level. Also, there is a significant link between OA degree with high levels of leptin.

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