Combined treatment of fractional carbon dioxide laser, 5 Flurouracil, and narrow band ultraviolet B for vitiligo: A prospective, randomized comparative trial

Authors

1 Professor of Dermatology, Venereology and Andrology, Faculty of Medicine for males, Cairo Branch, Al- Azhar University, Egypt

2 MBBcH of Dermatology, Venereology and Andrology, Faculty of Medicine for males, Cairo Branch, Al- Azhar University, Egypt

Abstract

Background: Vitiligo is a chronic cutaneous disorder that is marked by patches of hypopigmentation that can have a psychological impact on individuals. This research seeks to assess and contrast the efficiency of combined treatment with NB-UVB, 5-FU, & fractional CO2 laser for those with non-segmental vitiligo, as these new treatment modalities have been shown to reduce the treatment duration and associated adverse effects. Patients and methods: Thirty cases with stable NSV were selected. 4 patches within each patient were assigned randomized. First patch received 4 sessions of ID injection of 5-Fu with 2 weeks interval. Second patch received 4 sessions of Fr CO2 laser followed by ID 5- Fu injection with 2 weeks interval. Third patch received 4 sessions of Fr CO2 laser with 2 weeks interval. Fourth patch left as a control. All patches received a NB-UVB session twice per week. Results: There was significant repigmentation observed in patches treated with ID 5-FU alone (P0 < 0.045) followed by patches treated with Fr CO2 followed and ID 5-FU. Infection, scarring, and the Koebner phenomena were not observed in any of the cases. Conclusion: Fr CO2 laser followed by ID 5-FU can be considered as effective and safe method in the treatment of vitiligo. ID injection of 5-FU showed superior results.

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