Role of Silodosin Therapy after Shock Wave Lithotripsy for Upper Urinary Tract Stones in Children "Prospective Randomized Study"

Authors

1 Faculty of Medicine – Tanta University Resident of Urology – Zefta General Hospital

2 Assistant Professor of Urology Faculty of Medicine – Al-Azhar University (Cairo)

3 Fellow of Urology Faculty of Medicine – Al-Azhar University (Cairo)

Abstract

Background: Children with upper urinary stones were treated using shockwave lithotripsy (SWL). Although it may encourage the transit of stone fragments after SWL, the effectiveness of adjuvant silodosin therapy is still unknown. Aim of the work: Assess efficiency and safety of silodosin therapy post-SWL in children with upper urinary stones. Patients and Methods: Sixty patients were allocated and randomized into two groups of 30 each. Two patients were lost to follow-up (one in each group). All patients had a unilateral, single, radiopaque renal stone of(each 29 cases); group I received silodosin; and group II received placebo. Patients were followed up biweekly for 4 weeks. Results: Mean (SD) stone size for groups were 9.70 ± 3.10 and 9.27 ± 2.13 mm, respectively. Regarding stone location; upper stones were higher in placebo group and lower stones were higher in silodosin group. Energy power setting (KV) used and duration of SWL-session were significantly higher in group I. Noticed stone passage was 75.9% in group I and 58.6% in group II. Stone-free rate after 2 weeks of treatment was 51.7% in group I, compared with 17.2% in group II. Stone free rate at 4-weeks was 24.1% in group I vs. 41.4% in group II. Conclusion: Children with upper urinary stones can be safely treated with silodosin therapy post-SWL to speed up stone clearance and improve fragment removal.

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