Inverse Versus Forward IMRT Planning in Adjuvant Conventional Radiotherapy in Left Breast Cancer in correlation to cardiac constraints (A Retrospective Study)

Background: When treating breast cancer, intensity-modulated radiation treatment (IMRT) planning minimizes radiation exposure to organs at risk, like the heart, while optimizing dose distribution to the target volume. Numerous research works have contrasted the dosimetric benefits of inverse IMRT planning with traditional methods, exhibiting decreased cardiac dosages and enhanced target coverage. Aim of the work: To compare the left ventricle (LV) and left anterior descending artery (LAD) dosimetric parameters from the IMRT plan with the forward plan for patients with left breast cancer. Materials and Methods: From January 2022 to January 2024, the Clinical Oncology Department at El-Hussein University Hospital performed a retrospective analysis on twenty patients with left-sided breast cancer who had previously received radiation therapy. Results: The mean PTV max for patients who received 3DCRT was 109.6%±1.7, while in those who received IMRT was 110.2%±3.6, respectively, p=0.319. On the other hand, the mean PTV min for patients who received 3DCRT was 67.3%±15.4, while in those who received IMRT was 65.3%±13.7, p=562. Conclusions: According to this study's dosimetric comparison, the FIF-IMRT approach is superior to 3D-CRT, particularly in terms of target homogeneity and dose uniformity.