Relationship of Neutrophil to Lymphocyte Ratio (NLR) With Bone Markers and Vascular Changes in Chronic Kidney Disease Patients

Authors

1 Department of Internal Medicine and Nephrology, Faculty of Medicine for boys, Al-Azhar University, Cairo, Egypt

2 Department of Clinical Pathology, Faculty of Medicine for boys, Al-Azhar University, Cairo, Egypt

3 M.B.B.CH. – Al-Azhar University, Resident of Internal Medicine

Abstract

Background: The neutrophil/lymphocyte ratio (NLR), which increases during inflammation and may be linked to a worse prognosis in CKD, has been the subject of several recent research. Aim and objectives: The objective of the current study was to investigate how individuals with chronic renal disease's neutrophil lymphocyte ratio (NLR) correlated with bone markers and vascular alterations. Patients and methods: This was a prospective case control study which done at Nephrology Department, Ahmed Maher Teaching Hospital, Cairo, Egypt. The study was conducted over a one-year duration, from October 2021 till October 2022. Results: Serum vitamin D showed a significant decline in patients with CKD compared to controls, as it had mean values of 30.34, 20.43, and 20.56 ng/ml in the study groups respectively (p < 0.001). On the other hand, serum PTH had increased levels in CKD groups compared to controls, as it had median values of 40, 101.8, and 391.5 pg/ml in the three study groups respectively. Conclusion: End stage renal disease is associated with a significant increased carotid IMT, reflecting atherosclerotic burden in such patients. CKD is not associated with significant changes in NLR. NLR is not significantly correlated with either bone or vascular changes in CKD patients. Therefore, it should not be used to monitor these changes in the CKD setting.

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