Maternal and Fetal Plasma Urocortin Levels in pregnancies Complicated by Preeclampsia

Authors

1 Obstetrics and Gynecology, Faculty of Medicine, Al- Azhar University, Cairo, Egypt

2 Obstetrics and Gynecology, El Galaa Maternity Teaching Hospital. Cairo, Egypt

3 Clinical Pathology, El Galaa Maternity Teaching Hospital. Cairo, Egypt

4 Obstetrics and Gynecology, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt

Abstract

Background: Preeclampsia is a multisystem illness that manifests in the latter half of pregnancy as end-organ failure, proteinuria, or new-onset hypertension. Aims: seeks to assess urocortin levels in the plasma of the mother and fetus in 70 singleton pregnancies complicated by preeclampsia and in an additional 70 healthy, normotensive singleton pregnancies. Patients and Methods: After receiving approval from the research and ethical council, this case-control study was carried out at El Hussein University Hospital between November 2022 and December 2023.140 pregnant women having singleton pregnancies were included in this investigation and divided into two categories. The control group consisted of 70 healthy, normotensive singleton pregnancies that went on to deliver a healthy term baby. Pregnant women with singletons exacerbated by preeclampsia (n = 70; one case against one healthy control) made up the study group). Results: We recommend that an additional study be done on this biochemical marker since it has a strong correlation with preeclampsia and elevated levels of urocortin in both the mother and the fetus in preeclamptic instances. Conclusion: Preeclampsia cases have higher plasma urocortin levels in the mother and fetus than in the control group. Additionally, preeclampsia patients have a considerable impact on the middle cerebral artery and uterine artery Doppler indices.

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