Pretreatment With Letrozole Plus Misoprostol Versus Misoprostol Alone In Induction Of Missed Miscarriage

Background: Abortion, also known as miscarriage, is a common pregnancy problem that can happen naturally or be induced in order to terminate a pregnancy before the fetus has a chance to survive outside the uterus. Ten to twenty percent of all clinically confirmed pregnancies end in a missed miscarriage. Aim & objectives: to compare between repercussions of Letrozole plus Misoprostol also Misoprostol alone by means of inducing missed miscarriage. Subjects & methods: This comparative trial was performed on 74 cases who were recruited from the patients presenting in the outpatient obstetric clinic or the Emergency department in Al-Hussein & Sayed Galal Hospitals, Al-Azhar University. Result: Time (in hours) among first misoprostol dose as well as onset of vaginal spotting changed significantly amongst each of the groups (p=0.04), with the amount of time it took for the bleeding to stop after taking the first misoprostol dose in hours, (P below 0.001). univariate correlation regression between the outcomes and age, BMI, gravidity, previous CSs, and gestational age and Multivariate correlation regression between the outcomes and age, BMI, gravidity, previous CSs, and gestational age. There was no statistically significant alteration amongst both groups as regard demographic data, side effects and outcome. Conclusion: When letrozole along with misoprostol were used together, the time during induction and expulsion of conception products was shortened in women with delayed miscarriage without substantial problems, in addition the rate of complete miscarriage was increased.