Level of Interleukin-17 in Juvenile Idiopathic Arthritis and its Relation to Uveitis and Disease Activity

Authors

1 Rheumatology and Rehabilitation, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt

2 Clinical Pathology, Faculty of Medicine for Boys, Al-Azhar University, Assiut, Egypt

Abstract

Background: Arthritis that lasts longer than six weeks and causes painful swelling and limited movement in the joints is known as juvenile idiopathic arthritis (JIA). Arthralgia, on the other hand, can cause inflammation in addition to joint discomfort. Females are more likely to experience JIA than males. Aim and objectives: The goals of this study are(1) to determine the degree of interleukin-17A (IL-17A) in JIA patients' serum and synovial fluids using enzyme-linked immunosorbent assays (ELISAs) and(2) to establish a relationship between IL-17A levels and disease activity markers, including ultrasonography, uveitis, and laboratory parameters. Patients and methods: Patients at Al-Azhar-Assiut University Hospital's rheumatology, physical medicine, and rehabilitation departments served as subjects in this case-control study. An equal number of healthy control subjects and thirty JIA patients participated in this research. Results: Regarding erosion, grades I, II and III were observed in 11(36.67%), 14(46.67%) and 5(16.67%) cases, and IL-17 levels were 162.47±19.46, 214.11±16.76 and 240.2±14.4 respectively. Regarding Synovial Hypertrophy, grades Minimal, Mild, Moderate and Severe were observed in 5(16.67%), 12(40%), 9(30%), and 4(13.33%), and IL-17 levels were 154.54±18.53, 174.88±23.58, 216.06±17.05 and 240.2±14.4 respectively. Conclusion: Serum and synovial levels of interleukin-17A was a potential biomarker for JIA in children. Elevated level of IL-17A was significantly associated with JIA and can be used to monitor disease activity.

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