Ovarian Reserve in Postpubertal Females with Juvenile Onset Idiopathic Arthritis

Authors

1 Rheumatology, Childhood disabilities center, Al-Azhar University, Cairo, Egypt

2 clinical pathology, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt

Abstract

Background: Juvenile onset idiopathic arthritis is a chronic inflammatory disease that predominantly affects females in their early reproductive years, rendering the importance of considering ovarian reserve and future fertility, which may still be underappreciated. Objectives: This study aimed to explore the effects of juvenile-onset idiopathic arthritis on ovarian reserve in postpubertal female patients. Patients and methods. Thirty-one postpubertal female patients with juvenile-onset idiopathic arthritis and 25 healthy, age-matched controls were recruited in the study. The serum level of anti-Mullerian hormone (AMH) was assessed as a biomarker of ovarian reserve. Results: The mean present age was comparable in patients and controls 19.7± 3.4 vs 20.1±2.6 years, p = 0.65. AMH's mean serum concentration was comparable in JIA patients and healthy controls, 4.6±5.1 ng/mL vs 4.9±2.6 ng/mL, p = 0.65. The serum AMH levels of JIA patients receiving MTX and healthy controls did not differ significantly. 4.5±7.4 ng/mL vs 4.9±2.6 ng/mL, p = 0.39. Conclusion: AMH blood levels do not seem to indicate that juvenile onset idiopathic arthritis disease and immunosuppressive medication diminish ovarian reserve in postpubertal females.

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