Pregnancy outcome of extended culture of day 3 to day 5 frozen thawed day 3 embryos Versus Day 5 Frozen–Thawed Embryos

Authors

1 Embryology, Genetic Engineering and Biotechnology Research Institute, Cairo, Egypt

2 Obstetrics and Gynecology, International Islamic Institute for Population Studies and Researches (IICPSR), Al-Azhar University Egypt

3 Occupational Health and Industrial Medicine, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt

4 Embryology, International Islamic Center for Population Studies and Researches (IICPSR), Al-Azhar University Egypt

Abstract

Background: Cryopreservation is a useful technique utilized in assisted reproductive technology (ART). Frozen-thawed embryo transfer allows for the selective transfer of single embryos. Purpose: To compare the effectiveness of thawing day 3 embryos and culturing them for transfer as blastocysts versus transferring thawed frozen blastocysts in improving clinical pregnancy rates. Methods: This prospective cohort clinical investigation examined the frozen embryo transfer (FET) cycles of 120 cases with 1ry or 2ry infertility who had more than four high-quality embryos. The embryos were cryopreserved on either day 3 or day five. The clinical and laboratory data have been obtained from the International Islamic Institute for Population Studies and Research (IIIPSR), Al Azhar University assisted reproductive technology (ART) unit, between 2022 and 2023. Results: Group A shows a statistically significant higher percentage compared to Group B in clinical pregnancy (75% compared to 55.9%; p0.0 29). BMIs were comparable between the groups. (26.1 ± 3.3 vs. 23.6 ± 4.8, p-value equal 0.107) and infertility duration (4.6± 2.5 vs. 5.5 ± 4, p = 0.303 for group A and group B, respectively). Conclusion: This investigation exhibited that freezing cleavage embryos, then culturing and transferring them as blastocysts, results in higher rates of pregnancy than thawed blastocyst embryo transfers. Also, we suggested that blastocyst development after freezing cleavage-stage embryos accurately predicts embryo viability and pregnancy outcome. We concluded that the day three to five group had better chances of clinical pregnancy than the day five group.

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