Comparative study between oral and vaginal administration of misoprostol in the induction of labour in cases with premature rupture of membranes (PROM)

Authors

1 Department of Obstetrics and Gynecology, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt.

2 Department of Obstetrics and Gynecology, Faculty of Medicine for boys, Al-Azhar University, Cairo, Egypt

3 Department of Obstetrics and Gynecology, Air force hospital, Cairo, Egypt.

Abstract

Background: Cervical ripening is mediated by membrane-bound G-coupled receptor prostaglandins. Boost leukocyte extravasation and collagenase. Biochemical mechanisms alter the distribution of proteoglycan and collagen, allowing cervical effacement and dilatation. The use of PG gel for induction began in the 1980s. Prior to the 1990s, oral PG was avoided for induction of labour due to its unpleasant gastrointestinal effects. Oral route may improve mother satisfaction more than vaginal route. Aim: What is the difference between the effect of oral and vaginal misoprostol for induction of labor in pregnant females with PROM regarding efficacy, safety, maternal and fetal outcomes? Subject and Methods: 100 Pregnant females presenting at Obstetrics and Gynaecology emergency department at El-Hussein University hospitals. Results: There was no significant difference between the two groups regarding cesarean section indications Neonatal outcomes and Maternal outcomes. Conclusion: Researchers investigated the vaginal and oral safety and efficacy of misoprostol. To obtain the desired results, a different schedule and greater doses were administered. This study demonstrates that oral misoprostol is as safe and effective as its vaginal counterpart. Misoprostol administered orally or vaginally was equally effective for initiating labour in preterm women. To identify the ideal oral and vaginal dosage, additional research is required. In a facility that does emergency C-sections, it can be used to induce labour.

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