Evaluation of Plasma Level of Anticoagulant Proteins (Protein C, S and Anti thrombin III) in Patients with Acute Lymphoblastic Leukemia

Authors

1 Department of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo

2 Department of Clinical Pathology, Kobri El koba military Hospital

Abstract

Background: Acute lymphoblastic leukemia (ALL) is related to many coagulation abnormalities like hemorrhage & thrombosis. Objectives: research was to assess role of plasma activity levels of anticoagulant proteins in studied cases with acute lymphocytic leukemia. Patients and techniques: We researched thirty patients with confirmed ALL admitted in ELhussin or Said galal Hospital and twenty apparenty healthy as control group. Protein C, Protein S & Anti thrombin III are measured by coagulation analyzer (STAGO). Results: The mean activity levels of protein C (p=zero), Protein S (P=zero) & Anti thrombin III (p=zero) are highly significant lower in studied cases group compared to control group. Conclusion: The hypercoagulability state in ALL patients may attribute to the low level of protein C, protein S & Anti thrombin III.

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