Cleavage Stage versus Blastocyst Stage Fresh Embryo Transfer in Advanced Maternal Age

Authors

1 Obstetrics and Gynecology, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt

2 Obstetrics and Gynecology, International Islamic Center for Population Studies and Research (IICPSR), Al-Azhar University, Cairo, Egypt

Abstract

Background: As women aged, their ability to procreate naturally diminished. Fertility hit rock bottom at 45 years of age, with a precipitous drop after the age of 30 and a rapid acceleration between the ages of 35 and 40. Aim and objectives: To assess the clinical pregnancy rate of fresh embryo transfers performed at the cleavage stage against the blastocyst stage in women aged 35–40 who have had intracytoplasmic sperm injection (ICSI). Patients and methods: Sixty women, aged 35–40, were divided into two groups for this study, which took place at the Assisted Reproductive Unit of the International Islamic Centre for Population Studies and Research (IICPSR) at Al-Azhar University in Cairo, Egypt. Groups were blastocysts and cleavage. Results: There was no statistically significant difference between the blastocyst and cleavage groups regarding total gonadotrophin dose, estradiol (E2) at HCG, and progesterone at HCG, according to hormones at human chorionic gonadotropin (HCG). Results showed no statistically significant difference between the blastocyst and cleavage groups with respect to chemical pregnancy (serum-B HCG), clinical pregnancy as measured by ultrasound, or intrauterine pregnancies with embryonic heart rate. Conclusion: In terms of chemical pregnancy rate (as measured by serum B HCG) and clinical pregnancy rate (as measured by ultrasound—intrauterine pregnancies with embryonic heart pulsation), the Blastocyst and Cleavage groups did not vary statistically.

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