Impact of Pulse Steroid on the Level of IL-17 in Active Lupus Nephritis

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1 Internal Medicine, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt

2 Clinical Pathology, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt

Abstract

Background: Lupus nephritis (LN) is one of the most severe conditions associated with systemic lupus erythematosus (SLE). Interleukin-17 is one of the main inflammatory cytokines linked to LN, but the relationship is unclear. Aim of the work: Examine the correlation between the histopathological findings, therapy response, and IL-17 serum level in cases with active LN and following pulse therapy. Patients and methods: The current research divided 60 subjects into active LN, inactive LN, and control groups. Every individual underwent comprehensive history taking, a comprehensive physical examination, an evaluation of disease activity using the SLE disease activity index (SLEDAI), and clinical tests (including serum IL-17 levels). After the induction therapy, cases with active LN were followed up to determine the fate after treatment and to determine changes in the laboratory and urinary tested parameters. Results: Compared to the inactive LN and control groups, the active LN group had statistically significantly higher IL-17 levels. The IL-17 level in the active LN showed a statistically significant decrease after treatment compared to before treatment. Conclusion: In cases of SLE, a higher serum IL-17 level may help predict the level of LN activity. Active LN patients' serum IL-17 levels are predictive of treatment efficacy.

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