Immunological Impact of Ovarian Cystectomy in Cases of Laparscopic Procedure and Conventional Laparotomy

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Obstetrics and Gynecology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt

Abstract

Background: Conventional and laparoscopic surgery can impact a patient's immune status. Laparotomy causes more tissue trauma, while laparoscopy uses more cauterization, making both procedures potentially dangerous for the immune system. Aim and objectives: To compare both laparoscopic and open ovarian cystectomy regarding their immunological consequences on ovarian tissue by assessing the production of antiovarian and antinuclear antibodies. Patients and methods: This quasi-experimental clinical trial was conducted on 80 women aged ranged from 18 – 40 years who presented with ovarian cysts and were categorized into two groups: Group (1): (Laparotomy group): Involved 40 women who underwent open ovarian cystectomy and Group (2): (Laparoscopic group): Included 40 women, underwent for laparoscopic ovarian cystectomy. Results: Insignificant variance among the two groups was observed according to the development of tumor markers and regarding Antinuclear Antibodies (ANA) and Anti-Ovarian Antibodies (AOA) development before ovarian cystectomy and 1, 3 months after ovarian cystectomy (P-Value 0.632). A significant variance was observed among tumor markers (CA125) and types of ovarian cysts by ultrasound (P-Value 0.045) (66.7% of patients had multilocular cysts by U/S associated with positive CA 125). Conclusion: Both methods of removal of ovarian cysts, either laparoscopy or conventional laparotomy, do not affect the immune system and are not associated with developing antiovarian and antinuclear antibodies.

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